Center for Platelet Function Studies



Mark I. Furman, MD

Original Reports

1. Kaplan DT, Furman MI, Pincus SM. Techniques for Analyzing Complexity in Heart Rate and Beat to Beat Blood Pressure Signals. Computers in Cardiology, 1991.

2. Kaplan DT, Furman MI, Pincus SM, Ryan SM, Lipsitz LA, Goldberger AL. Aging and the Complexity of Cardiovascular Dynamics. Biophys J 59: 945-49, 1991

3. Ivanhoe, RJ, Weintraub WS, Douglas JS Jr., Lembo NJ, Furman M, Gershony G, Cohen CL, King SP III, Percutaneous Transluminal Coronary Angioplasty Of Chronic Total Occlusions: Primary Success, Restenosis, And Long Term Clinical Follow-Up. Circulation 85;106-15, 1992.

4. Goldschmidt-Clermont PJ, Furman MI, Wachstock D, Safer D, Nachmias VT, Pollard TD. The Control of Actin Nucleotide Exchange by Thymosinb4 and Profilin. A Potential Regulatory Mechanism for Actin Polymerization in Cells. Molec Biol Cell 3:1015-24 1992.

5. Furman MI, Gardner TM, Goldschmidt-Clermont PJ. Mechanisms of Cytoskeletal Reorganization during Platelet Activation. Thromb and Haemost 70 229-232.1993.

6. Furman MI, Grigoryev D, Bray PF, Dise KR Goldschmidt-Clermont. Platelet Tyrosine Kinases and Fibrinogen Receptor Activation. Circ Res 75:172-80, 1994.

7. Furman MI, Becker RC, Yarzbeski J, Savageau J. Gore JM, Goldberg RJ. Effect of Elevated Leukocyte Count on In-Hospital Mortality Following Acute Myocardial Infarction. Am J Cardiol 78:945-48, 1996.

8. Michelson AD, Benoit SE. Furman MI, Breckwoldt WL., Rohrer MJ, Barnard MR, Loscalzo J. Effects of Endothelium-derived Relaxing Factor/Nitric Oxide on Platelet Surface Glycoproteins. Am J of Phys (Heart and Circulatory Physiology): 270:H1640-48, 1996

9. Michelson AD, Benoit SE, Furman MI, Barnard MR, Nurden P, Nurden AT. The Platelet Surface Expression of Glycoprotein V is Regulated by Two Independent Mechanisms: Proteolysis and a Reversible Cytoskeletal-mediated Redistribution to the Surface-connected Canalicular System. Blood 87:1396-1408, 1996

10. Sharma M, Furman MI, Spencer FA, Burns M, Ball SP, Becker, RC. Thrombolytic Therapy in Acute Myocardial Infarction: Management Algorithms J Thromb Thromboly, 4:397-413, 1997.

11. Sharma M, Furman MI, Spencer FA, Burns M, Ball SP, Becker, RC. Current and Practical Management of Acute Myocardial Infarction. J Thromb Thrombolys , 4: 375-396 1997

12. Furman MI, Liu L, Benoit SE, Becker RC, Barnard MR, Michelson, AD. The Cleaved Peptide of the Thrombin Receptor is a Strong Platelet Agonist. Proc Natl Acad Sci, U.S.A. 95:3082-87, 1998

13. Furman MI, Benoit SE, Valeri CR, Borbone ML, Becker RC, Hechtman HB, Michelson AD. Increased Platelet Reactivity and Circulating Platelet-Monocyte Aggregates in Patients with Stable Coronary Artery Disease. J Am Coll Cardiol 31:352-8, 1998

14. Peyton BR, Rohrer MJ Furman MI, Barnard MR, Rodino LJ, Benoit SE, Hechtman HB, Valeri CB, and Michelson AD. Patients with venous stasis ulceration have increased monocyte-platelet aggregation. J Vasc Surg 27:1109-15, 1998.

15. Michelson AD and Furman MI Laboratory Markers of Platelet Activation and Their Clinical Significance. Curr Opin Hematol 6:342-348, 1999.

16. Powell CC, Rohrer MJ, Barnard MR, Peyton BD, Furman MI, and Michelson AD. Chronic Venous Insufficiency is Associated with Increased Platelet and Monocyte Activation and Aggregation. J Vasc Surg 30:844-51, 1999.

17. Furman MI. Markers of Platelet Activation. J Thromb Thromboly 9:81-84, 2000.

18. Michelson AD, Furman MI, Goldschmidt-Clermont P, Mascelli MA, Hendrix C, Coleman L, Hamlington J, Barnard M, Kickler T, Christie DJ, Kundu S, and Bray PJ. Platelet GPIIIa PLA Polymorphisms Display Different Sensitivity to Agonists. Circulation 101:1013-18, 2000.

19. Michelson AD, Barnard MR, Krueger LA, Frelinger AL, and Furman MI. Evaluation of Platelet Function by Flow Cytometry Methods. A Companion to Methods in Enzymology 21:259-70. 2000.

20. Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, Ballantyne CM, Zhang L, Furman MI, Berndt MC, Lopez JA. Platelet Glycoprotein Iba Is A Counter-Receptor for Leukocyte Integrin Mac-1 (CD11b/CD18). J Exp Med 192:193-204, 2000.

21. Michelson AD, Barnard MR, Krueger LA, Frelinger III AL, Furman MI. Evaluation of platelet function by flow cytometry. Purdue Cytometry. CD ROM volume 5, 2000.

22. Michelson AD, Barnard MR, Krueger LA, Frelinger III AL, Furman MI. Evaluation of platelet function by flow cytometry. Methods 21: 259-70, 2000.

23. Furman MI, Frelinger, AL and Michelson AD. Antithrombotic Therapy in the Cath Lab. Current Cardiology Reports 2:386-394, 2000.

24. Dauerman HL, Yarzebski J, Lessard D, Furman MI, Gore JM, and Goldberg RJ. TenYear Trends in the Incidence, Treatment and Outcome of Q Wave Myocardial Infarction: A Population Based Perspective. Am J Cardiol 86:730-735, 2000.

25. Furman MI, Krueger LA, Frelinger AL, Barnard MR, Mascelli MA, Nakada MT, and Michelson AD. GPIIb-IIIa Antagonist-induced Reduction in Platelet Surface Factor V/Va Binding and Phosphatidylserine Expression in Whole Blood. Thromb and Haemost 84:492-8, 2000.

26. Furman MI, Nurden P, Berndt MC, Nurden AT, Benoit SE, Liu L, Rohrer MR, Barnard MR, and Michelson, AD. The Cleaved Peptide of PAR1 Results in a Redistribution of Platelet Surface GPIb to the Surface-Connected Canalicular System. Thromb and Haemost 84:897-903, 2000.

27. Claytor BR, Li J-M, Furman MI, Garnette CSC, Rohrer MJ, Barnard MR, Krueger LA, Frelinger AL, Michelson AD. Laser scanning cytometry: a novel method for the detection of platelet-endothelial cell adhesion. Cytometry 43:308-313, 2001.

28. Furman MI, Dauerman HL, Goldberg RJ, Yarzbeski J, Lessard D, and Gore JM. Twenty-Two Year (1975-1997) Trends in the Incidence, In-Hospital and Long-Term Case-Fatality Rates from Initial Q Wave and Non-Q Wave Myocardial Infarction: A Multi-Hospital, Community-Wide Perspective. J Am Coll Cardiol 37:1571-80, 2001.

29. Michelson AD, Barnard MR, Krueger LA, Frelinger AL, and Furman MI. Flow cytometry and other methods for the detection of circulating activated platelets. In Gresele P, Page CP, Vermylen J, Fuster V (eds). Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology, and Therapeutics. Cambridge University Press, Cambridge, in press, 2001

30. Bray PF, Goldschmidt-Clermont P, Furman MI, Michelson AD, Barnard MR, Mascelli MA, Hendrix C, Coleman L, Hamlington J, Kickler T, Christie DF, and Kundu S. Platelet glycoprotein IIIa PlA polymorphism and effects of aspirin on thrombin generation. Circulation 103:e33-e34, 2001 (letter).

31. Michelson AD, Barnard MR, Krueger LA, Valeri CR and Furman MI. Circulating Monocyte-Platelet Aggregates Area More Sensitive Marker of Platelet Activation Than Platelet Surface P-Selectin: Studies in Baboons, Human Coronary Intervention, and Human Myocardial Infarction Circulation 104:1533-1537, 2001

32. Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, Lessard DM, Marchese P, Frelinger III, AL, Goldberg RJ, and Michelson AD. Circulating Monocyte-Platelet Aggregates are an Early Marker of Acute Myocardial Infarction. J Am Coll Cardiol 38:1002-1006, 2001.

33. Frelinger AL, Furman MI, Krueger LA, Barnard MR, and Michelson AD. Dissociation of glycoprotein IIb/IIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation. Circulation 104:1374-1379, 2001

34. Furman MI, Kereiakes DJ, Krueger LA, Mueller MN, Pieper K, Broderick TM, Schneider JF, Howard L, Fox ML, Barnard MR, Frelinger AL, and Michelson AD. Leukocyte-Platelet Aggregation, Platelet Surface P-Selectin, and Platelet Surface GPIIIa Following Percutaneous Coronary Intervention: Effects of Dalteparin or Unfractionated Heparin in Combination with Abciximab. Am Heart J 142:790-798, 2001

35. Michelson AD, Barnard MR, Krueger LA, Frelinger AL, and Furman MI. Flow cytometry and other methods for the detection of circulating activated platelets. In Gresele P, Page CP, Fuster V, Vermylen J (eds). Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology, and Therapeutics. Cambridge University Press, Cambridge, in press, 2001

36. Krueger LA, Barnard MR, Frelinger AL, Furman MI, and Michelson AD. Immunophenotypic analysis of platelets. In Robinson JP, Darzynkiewicz Z, Dean P, Orfao A, Rabinovitch P, Tanke H, Wheeless L (eds). Current Protocols in Cytometry. John Wiley & Sons, New York, in press, 2002.

37. Michelson AD, Barnard MR, Krueger LA, Frelinger AL, and Furman MI. Flow cytometry. In Michelson AD (ed). Platelets. Academic Press, New York, 297-319, 2001.

38. Krueger LA, Barnard MR, Frelinger AL, III, Furman MI, and Michelson AD. Immunophenotypic analysis of platelets. In Robinson JP, Darzynkiewicz Z,Dean PN, Dressler LG, Rabinovitch PS, Stewart CC, Tanke HJ, Wheeless LL(eds). Current Protocols in Cytometry. John Wiley & Sons, New York,1:6.10.1-6.10.17, 2002.

39. Wheeler GL, Braden GA, Kereiakes DJ, Kottke-Marchant K, Michelson AD, Furman MI, Mueller M, Moliterno DJ, and Sane DC. The Accumetrics Ultegra-RPFA: a study of equivalence to standard platelet function assays in patients undergoing percutaneous coronary intervention with abciximab therapy. Submitted for publication.

40. Marciniak SJ, Mascelli MA, Furman MI, Michelson AD, Jakubowski JA, Jordan RE, and Frelinger AL. An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates. Thromb Haemost 87:1020-5, 2002.

41. Frelinger AL, Furman MI, Krueger LA, Barnard MR, and Michelson AD. Activating effects of GPIIb/IIIa blockers: an intrinsic consequence of ligand-mimetic properties. Response. Circulation 105:180e-181e, 2002 (letter).

42. Furman MI, Kereiakes DJ, Krueger LA, Mueller MN, Broderick TM, Schneider JF, Howard WL, Fox ML, Barnard MR, Frelinger AL, and Michelson AD. Quantification of abciximab-induced platelet inhibition is assay dependent: A comparative study in patients undergoing percutaneous coronary intervention. in press, Am Heart J: 2002.

43. Rashkin, J and Furman MI. Long term trends in fatality rates from myocardial infarction. in press Cardiovasc Rev Reports: 2003.

44. Rohrer MJ, Claytor RB, Garnette CSC, Powell CC, Barnard MR, Furman MI, and Michelson AD. Platelet-monocyte aggregates in patients with chronic venous insufficiency remain elevated following correction of reflux. Submitted for publication.

45. Garnette CSC, Barnard MR, Furman MI, Rohrer MJ, Frelinger AL, Claytor RB, Krueger LA, and Michelson AD. Proteolysis of platelet surface P-selectin and disaggregation of leukocyte-platelet complexes by cathepsin G. Submitted for publication.

46. Furman MI, Frelinger AL, and Michelson AD. GPIIb/IIIa Inhibitor-induced Dethrombosis. Submitted to Circulation.

47. Furman MI, Gore JM, Anderson FA, Budaj A, Goodman SG, Avezum A, MD3, López-Sendón J, Klein W, Mukherjee D, Eagle KA, Dabbous OH, and Goldberg RJ for the GRACE Investigators. Relationship Between Elevated Leukocyte Count and Hospital Events in Patients with Acute Coronary Syndromes: Findings from the Global Registry of Acute Coronary Events (GRACE). Submitted for publication, J Am Coll Cardiol.